Opening Ceremony

8.30-10.00 / Monday 13

Michel REYNAUD, ISBRA 2010 Organizer

Toshikazu SAITO, ISBRA President

Michel LEJOYEUX, SFA President

Roselyne BACHELOT-NARQUIN, French Minister of Health, or her Representative

Kenneth WARREN, National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Symposia

10.30-12.00 / Monday 13

14A - Prevention	Room A - Simultaneous translation
Prevention of alcohol related problems: Between science, ideology and politics

Alain RIGAUD, France (Co-chair)

Hélène SIMONEAU, Canada - Alcochoix+: A program on managing alcohol use

Tiziana CODENOTTI, Belgium - Alcohol policies from an NGO’s perspective: EUROCARE - The european alcohol policy alliance

Maria RENSTROM, Sweden - Process leading up to the EU alcohol strategy and the global alcohol strategy. Focus on how science was conducted in parallel to the policy process

Michel CRAPLET, France (Co-chair) - Prevention of alcohol related problems at risk of ideology and politics

14C - Prevention	Room B
Alcohol policy development: From evidence to action Joint ISBRA-WHO session

Susumu HIGUCHI, Japan (Co-chair)

Thomas BABOR, USA - Effectiveness of strategies and interventions to reduce alcohol-related harm: An update

Daniel CHISHOLM, Switzerland - Economics of alcohol control

Ann HOPE, Ireland - A roadmap for implementation of effective action on reducing harmful use of alcohol

Vladimir POZNYAK, Switzerland (Co-chair) - WHO global strategy to reduce harmful use of alcohol: A call for global action

4C - Determinants of alcohol consumption in humans	Room C
Experimental laboratory models in alcohol research: Translating from the lab to the clinic

Abigail ROSE, United Kingdom (Co-chair and Discussant)

Lara RAY, USA (Co-chair) - Laboratory phenotypes for alcoholism as predictors of alcohol use and treatment response

Matt FIELD, United Kingdom - Manipulation of inhibitory control processes influences drinking behaviour

James MACKILLOP, USA - Understanding impulsivity and alcohol misuse via delayed reward discounting

James MURPHY, USA - Modeling response to brief alcohol interventions using a behavioral economic measure of reinforcement value

6A - Fetal Alcohol Syndrome/Development	Room D
Behavioral and neurochemical effects of alcohol on the developing brain

Ricardo M. PAUTASSI, Argentina (Co-chair)

Alexandre MEDINA, USA - Improvement of SRF function in astrocytes can restore neuronal plasticity in a model of fetal alcohol spectrum disorders

Rosana CAMARINI, Brazil (Co-chair) - Differential behavioral response to ethanol in adolescent mice: Implication for the role of cAMP-responsive element binding factor (CREB) and BDNF

Elena VARLINSKAYA, USA - Endogenous opioid systems and the social consequences of ethanol in adolescence

María PASCUAL, Spain - Vulnerability of adolescence in ethanol-induced stimulation of the mesolimbic dopamine response

13A - Physiology CNS	Room E
Stopped at the gate: Modulation of information flow into the cerebellum by alcohol

Lia FORTI, Italy (Co-chair) - Activation of cerebellar inhibitory loops: Evidence for novel granule cell-Golgi cell contacts in the granular layer

Fernando VALENZUELA, USA (Co-chair) - Ethanol excites cerebellar Golgi cells: Role of Na+/K+ ATPase inhibition

Erik DE SCHUTTER, Japan - Computational modeling of the mechanisms of ethanol effects on cerebellar neurons

Chi-Ming HUANG, USA - Discharge patterns of cerebellar Golgi cells and granule cells in the unrestrained rat before and after ethanol

Mario CARTA, France (Discussant)

1A - Animal Behavior	Room F
Transitions to excessive alcohol consumption: Animal models

Selena BARTLETT, USA - Modulation of ethanol intake in rats

Nicholas GILPIN, USA - Extending the utility of alcohol vapor dependence procedures

Valentina VENGELIENE, Germany (Co-chair) - Compulsive alcohol drinking in rodents

John C. CRABBE, USA (Co-chair) - Mice drinking in the dark: Selective breeding for excessive alcohol

Poster Session

12.00-13.00 / Monday 13

Symposia

13.00-14.30 / Monday 13

8A - Health Services	Room A - Simultaneous translation
Care devices for alcohol problems. What could be the best device?

Benoît FLEURY, France (Co-chair)

Ioannis MOUZAS, Greece - Care devices for alcoholic patients in Southern Europe

Gerard M. SCHIPPERS, The Netherlands - Care devices for alcoholic patients in Northern Europe

François PAILLE, France (Co-chair) - Evolution of care device for alcoholic patients in France

Michel LANDRY, Canada - Care devices for alcoholic patients in North America. What could be the best device?

5B - Epidemiology	Room B
Women’s alcohol consumption and risk for alcohol-exposed pregnancies

Sharon WILSNACK, USA (Co-chair and Discussant)

Per NILSEN, Sweden - A systematic review of studies investigating predictors for drinking during pregnancy

Tatiana BALACHOVA, USA (Co-chair) - Women’s alcohol consumption and risk for alcohol-exposed pregnancies: Developing strategy for FASD prevention in Russia

Janna MALMSTEN, Sweden - The epidemiology of alcohol use prior to and during pregnancy in Sweden

So Hee LEE, Republic of Korea - Alcohol use during pregnancy and related risk factors in Korea

7A - Genetics	Room C
Role of epigenetics in alcoholism vulnerability: Novel therapeutic targets

Antonio NORONHA, USA (Co-chair)

Mickael NAASSILA, France (Co-chair) - Histone deacetylase inhibitor prevents operant ethanol self-administration in dependent and nondependent rats, ethanol relapse and the induction of ethanol-induced locomotor sensitization in mice

Georgy BAKALKIN, Sweden - Alcohol-induced shift in epigenetic mechanism: DNA demethylation in a single nucleosome may underlie prodynorphin upregulation in human alcoholics

Carles SANCHIS-SEGURA, Spain - Epigenetic mechanisms in drug addiction and its therapeutics: Focus on histone acetylation

Rajesh MIRANDA, USA - An ethanol-sensitive micro-RNA (miRNA) within an epigenetically programmed fetal growth-control locus prevents fetal neural stem cell maturation; a possible mechanism for ethanol neuroteratology

6B - Fetal Alcohol Syndrome/Development	Room D
Biomarkers of fetal ethanol exposure and fetal ethanol effects INSERM-NIAAA research program

Feng ZHOU, USA (Co-chair)

Vincent SAPIN, France - Limits of conventional alcohol biomarkers in cord blood at term: A fetal-maternal population-based study

Sridevi BALARAMAN, USA - Circulating microRNAs as biomarkers for fetal alcohol exposure

Daniel SAVAGE, USA (Co-chair) - Effects of moderate drinking during pregnancy on placental gene and protein expression

Bruno GONZALEZ, France - Prenatal alcohol exposure affects the development of the brain microvascular system: Involvement of the VEGF system

1C - Animal Behavior	Room E
Ethanol sensitization: Thirty years of research into its mechanisms and contributions to alcohol use disorders

Isabel QUADROS, USA (Chair)

Maria Lucia O. SOUZA-FORMIGONI, Brazil - Individual differences on sensitization to ethanol’s stimulant effects: Neurobiological factors associated with vulnerability or resilience

Raúl PASTOR, Spain - Role of corticotropin-releasing factor (CRF) in behavioral sensitization to ethanol

Robert SWIFT, USA - Ethanol’s stimulant effects and sensitization in humans: Clinical relevance

Tamara PHILLIPS, USA (Discussant)

1B - Animal Behavior	Room F
Emerging novel mechanisms of alcohol reinforcement and dependence

Friedbert WEISS, USA (Co-chair) - Behavioral and functional evidence of mGlu2/3 and mGlu5 metabotropic glutamate receptor (mGluR) dysregulation as a factor in the transition to drug and alcohol dependence: Implications for the treatment target potential of mGluRs

Andrew LAWRENCE, Australia (Co-chair) - mGlu5 receptor interactions with other GPCRS: Relevance to alcohol-seeking

Ivan DIAMOND, USA - A unique reversible ALDH2 inhibitor prevents alcohol drinking and relapse through a novel mechanism of action regulating dopamine homeostasis

Sheketha HAUSER, USA - Biological basis of EtOH-seeking in alcohol-preferring (P) rats: Novel systems and neuropeptides

Symposia

14.30-16.00 / Monday 13

8B - Health Services	Room A - Simultaneous translation
Alcohol problems in the workplace

Benoît FLEURY, France (Chair)

Valentina FORASTIERI, Switzerland - Preventing alcohol and drug abuse in the workplace: Evidence-based successful programmes. ILO work in the field of alcohol and drug abuse at the workplace

Claudine GILLET, France - Addictions and work: The interest of professional recommendations validated by the French High Authority of Health

Fatma BOUVET DE LA MAISONNEUVE, France - Active women and alcohol

Franck DROUIN, France - An example of French and Russian cooperation on prevention of alcohol related risk inside companies

19F - Treatment/Recovery	Room B
Addressing the full spectrum of alcohol and other drug problems in primary care

Robert HUEBNER, USA (Co-chair)

Constance WEISNER, USA (Co-chair) - Integrating primary care with alcohol and drug treatment in a continuing care model: Outcomes and cost impact

Richard SAITZ, USA - Effectiveness of chronic care management for alcohol and drug dependence: Addiction health evaluation and disease management (AHEAD) trial results

Gallus BISCHOF, Germany - Stepped-care intervention for alcohol problems: A cost-effective approach for brief interventions in primary care?

A. Thomas MCLELLAN, USA - New directions in drug policy: President Obama’s national demand reduction priorities

7H - Genetics	Room C
Changes in gene expression and genetic risk factors in alcohol dependence

Mary-Anne ENOCH, USA (Co-chair) - Chronic alcohol and cocaine exposure in the human brain: Effects on expression of stress response genes

Peter R. DODD, Australia - Connection failure: Genotype-phenotype interactions at the alcoholic synapse

Ulrich PREUSS, Germany - Genetic and behavioral risk factors for suicidal behaviour in alcohol dependence

Henry KRANZLER, USA (Co-chair) - Genetic moderation of adverse childhood events and risk of depression and substance dependence

6C - Fetal Alcohol Syndrome/Development	Room D
Fetal alcohol spectrum disorders (FASD): From molecules to man

Michael CHARNESS, USA (Chair) - Characterization of an alcohol binding site on the L1 neural cell adhesion molecule

Jennifer THOMAS, USA - Choline as a treatment for fetal alcohol spectrum disorders

Kathleen SULIK, USA - Magnetic resonance imaging-based analyses of a fetal alcohol spectrum disorders mouse model

Andrzej URBANIK, Poland - Impact of alcohol on the central nervous system in children prenatally exposed to alcohol: Magnetic resonance examination

12B - Pharmacology CNS	Room E
Ethanol and acetaldehyde metabolism: Central and peripheral effects

Etienne QUERTEMONT, Belgium (Chair)

Zachary RODD, USA - What is the basis of ethanol reinforcement: Ethanol, acetaldehyde, salsolinol, or all?

Marco DIANA, Italy - Ethanol, acetaldehyde and dopamine neurons

Lutske TAMPIER, Chile - Acetaldehyde protects against alcoholism but it also plays a role in the development of tolerance and dependence

Mostofa JAMAL, Japan - Acute alcohol effects and a role for acetaldehyde in memory in mice

Cindy EHLERS, USA - Association and linkage studies of ADH in Native and Mexican Americans

9A - Molecular/Cell Biology	Room F
Pathways to alcohol binding sites at atomic resolution

Adron HARRIS, USA (Co-chair)

Pierre-Jean CORRINGER, France - Atomic structure and allosteric regulation of bacterial channel-receptors from the cys-loop family

Erik LINDAHL, Sweden - Study by molecular dynamics simulations of Cys-loop potentiating effect: Binding of ethanol on glycine receptor stabilizes the open conformation

Paul SLESINGER, USA - Structure to function: A discrete alcohol pocket discovered in a potassium channel

James TRUDELL, USA (Co-chair) - Convergence among models, structures, and functional studies

Poster Session

16.30-18.00 / Monday 13

Welcome Cocktail Party at CAP 15

18.00-19.30 / Monday 13

Keynote Lectures

8.30-10.00 / Tuesday 14

Tamara PHILLIPS, Portland, USA

Genes and gene networks in alcohol and drug use disorders: Insights from animal models

Kenneth KENDLER, Richmond, USA

The genetic epidemiology of alcohol use and alcohol use disorders

Symposia

10.30-12.00 / Tuesday 14

3D - Consequences of alcohol consumption in humans	Room A - Simultaneous translation
Alcohol and human aggression: Recent research trends

Philippe ARVERS, France - Alcohol use and violence suffering or acting in France: The VAMM1 epidemiological survey

Laurent BEGUE, France (Chair) - An explanation of intoxicated aggression: The intentionality bias

Cheryl CHERPITEL, USA - Alcohol and violence-related injuries: Findings from cross-national emergency department data

Baptiste SUBRA, France - Alcohol and aggression: Automatic effects of alcohol cues on aggressive behaviors

Joel SWENDSEN, France - Violence and alcohol: Potential roles of pre-existing antisocial personality and behavior disorders

3C - Consequences of alcohol consumption in humans	Room B
Alcohol and hepatocarcinogenesis

Helmut K. SEITZ, Germany (Chair)

Philip BROOKS, USA - The role of acetaldehyde-DNA adducts in alcohol mediated carcinogenesis

Sebastian MUELLER, Germany - Oxidative stress major mechanisms in alcohol mediated hepatocarcinogenesis

Felix STICKEL, Switzerland - Alcohol epigenetics and cancer

Xiang-Dong WANG, USA - Interaction between alcohol and retinoids in hepatocellular cancer

7D - Genetics	Room C
Identifying genes affecting alcoholism using different strategies

Nick MARTIN, Australia (Chair) - Genomewide Association Study of quantitative alcohol phenotypes in community-ascertained families

Joel GELERNTER, USA - Genomewide studies of alcohol dependence

Howard EDENBERG, USA - Identifying genes affecting alcoholism in the COGA sample

Hugh GURLING, United Kingdom - Mapping of susceptibility genes explaining the comorbidity between the alcohol dependence syndrome and bipolar affective disorder

Kenneth KENDLER, USA - Genome-wide association analyses in the Irish affected sib pair study of alcohol dependence

4B - Determinants of alcohol consumption in humans	Room D
Models of risk for drinking and problems in adolescents and young adults

Marc SCHUCKIT, USA (Co-chair) - Testing an LR-based model of AUDs in three adolescent samples

Sawitri ASSANANGKORNCHAI, Thailand - Social contextual influences on underage drinking among Thai adolescents

Ulrich ZIMMERMANN, Germany - What laboratory stress response in young adults tells us about stress-induced drinking in real life

Victor HESSELBROCK, USA (Co-chair) - A prospective evaluation of alcohol use patterns and problems from the Hartford prospective study

12A - Pharmacology CNS	Room E
The role of neuropeptide systems in alcohol dependence

Thomas KASH, USA (Co-chair) - Kappa opioid receptor modulation of inhibitory transmission in the bed nucleus of the stria terminalis

Marisa ROBERTO, USA (Co-chair) - The role of neuropeptides on ethanol action in amygdalar GABAergic synapses: Which are pro and which are con?

Roberto CICCOCIOPPO, Italy - Central amygdala nociceptin/orphain FQ neurotransmission, stress and alcohol abuse

Emilio MERLO PICH, Italy - Pharmacological fMRI to study the role of neuropeptides on extended amygdala activation in rodents: Focus on the corticotropin releasing factor and the orexin/hypocretin systems

Jesse SCHANK, USA - Neurokinin 1 receptor (NK1R) antagonism a novel target for treatment of alcoholism

10A - Pathology: Human/Animal	Room F
Alcoholic liver disease: Clinical approach in 2010

Philippe MATHURIN, France (Chair)

Christopher P. DAY, United Kingdom - Susceptibility to ALD: Where are we?

Tim MORGAN, USA - Natural history of alcoholic liver disease: From normal liver to cirrhosis, decompensated cirrhosis and death

Michael R. LUCEY, USA - Pharmacological management of ALD: Where are we and where are we going?

Georges-Philippe PAGEAUX, France - Transplantation for alcoholic cirrhosis. Who and when?

Poster Session

12.00-13.00 / Tuesday 14

Symposia

13.00-14.30 / Tuesday 14

5A - Epidemiology	Room A - Simultaneous translation
Alcoholic liver disease - Public health approach Supported by an unrestricted educational grant of Inserm - Institut thématique santé publique

Bertrand NALPAS, France (Chair)

Mats RAMSTEDT, Sweden - Alcohol consumption and liver cirrhosis mortality - The population level link

Róza ADANY, Hungary - Composition of surrogate alcohols consumed in Hungary, Russia and Estonia

Jurgen T. REHM, Canada - The economic consequences of alcoholic liver disease

Victor DE LEDINGHEN, France - Assessment of liver fibrosis in alcoholic liver disease: Non-invasive methods or liver biopsy?

3B - Consequences of alcohol consumption in humans	Room B
Noninvasive screening for alcoholic liver cirrhosis by transient elastography

Michel BEAUGRAND, France (Co-chair) - Noninvasive diagnosis of cirrhosis by fibroscan: Principles and major experiences

Sebastian MUELLER, Germany (Co-chair) - Potential interferences with transient elastography: Can the liver become stiffer in the absence of cirrhosis?

Didier SAMUEL, France - Complications of liver cirrhosis: Does transient elastography improves the risk assessment?

Andreas ERHARDT, Germany - Transient elastography versus conventional serum markers and imaging: What is the better test for liver cirrhosis?

7F - Genetics	Room C
Convergent functional genomics of genome-wide association data for alcoholism: Comprehensive identification of candidate genes, pathways and mechanisms

Marcella RIETSCHEL, Germany (Co-chair) - Genome-wide association study of alcohol dependence

Gunter SCHUMANN, United Kingdom - Identification of genes associated with alcohol consumption

Rainer SPANAGEL, Germany (Co-chair) - Reverse genetic approaches for the functional validation of candidate genes for alcohol consumption and dependence

Christina BARR, USA - Genome-wide identification of epigenetic markers of early stress in Primate brain – Relevance to G x E interactions

4G - Determinants of alcohol consumption in humans	Room D
Novel applications for human lab studies with alcohol administration

Joop VAN GERVEN, The Netherlands - The central nervous system effects of alcohol in different populations, using a novel spreadsheet-based ethanol clamping paradigm

Ulrich ZIMMERMANN, Germany (Co-chair) - Intra-session variability of blood alcohol concentration during computer-assisted self-infusion of ethanol (CASE): A new measure reflecting alcohol apperception?

Vijay RAMCHANDANI, USA (Co-chair) - Recent drinking history predicts intravenous alcohol self-administration in social drinkers

Sean O'CONNOR, USA - Alcohol-dependent subjects employ computer-assisted self-infusion of ethanol to achieve high levels of brain exposure

Harriet DE WIT, USA (Discussant)

12H - Pharmacology CNS	Room E
Gender/sex differences in alcohol-related behaviors and neuronal injury: A graduate student perspective

Tracy BUTLER, USA (Co-chair) - Sex-dependent hippocampal injury: Adenosine receptor antagonism during ethanol withdrawal

Frédéric LALLEMAND, Belgium - The influence of chronic nicotine administration on behavioural and neurochemical parameters in male and female rats after repeated binge drinking exposure

Jessica WEAFER, USA (Co-chair) - Response conflict as an environmental determinant of gender differences in sensitivity to alcohol impairment

Sandra KUNTSCHE, Switzerland - Are housewives really desperate? The relevance of societal factors in the association between social roles and alcohol use among mothers

9I - Molecular/Cell Biology	Room F
"Trapping the fats" in alcoholic liver injury: Role of impaired lipid droplet trafficking and metabolism

Carol CASEY, USA (Co-chair)

Tobias WALTHER, Germany - The many phases of fat: Cell biology of lipid droplets

Benita MCVICKER, USA - Use of WIF-B cells to examine alcohol-induced alterations in lipid droplet trafficking: Potential mechanisms and role in hepatocellular damage

Mark MCNIVEN, USA (Co-chair) - Alcohol-induced impairments in hepatocellular Rab content and function: Role in impaired lipid droplet trafficking after ethanol administration

Zhanxiang ZHOU, USA - Zinc supplementation: Role in decreasing lipid droplet stores and reversing alcohol-induced steatosis in mice

Symposia

14.30-16.00 / Tuesday 14

14B - Prevention	Room A - Simultaneous translation
Using specific approaches in early identification and brief interventions for specific populations

Philippe MICHAUD, France (Co-chair)

Eileen F.S. KANER, United Kingdom (Co-chair)

Arlene FINK, USA - The Alcohol-related problems survey (ARPS) online: Results of an evaluation study on US older adults’ acceptance of online alcohol screening and education

Claude LEJEUNE, France - Written advice for pregnant women who drink through a "prevention touch-screen": Acceptability and feasibility in an obstetrical consultation of a public hospital

Dorothée LECALLIER, France - Development of alcohol (and other drugs)-related risk adolescents by school nurses and doctors in secondary school of Parisian Region, using DEP-ADO questionnaire and brief motivational interventions

10D - Pathology: Human/Animal	Room B
Mechanisms of alcohol on carcinogenesis and tumor progression

Helmut K. SEITZ, Germany (Co-chair) - Mechanisms of tumorgenesis associated with alcohol consumption

Mikko SALASPURO, Finland - Microbial acetaldehyde formation as a cumulative carcinogen in alcohol-mediated digestive tract cancers

Dipak SARKAR, USA - Increased susceptibility to prostate cancers in fetal alcohol exposed offspring: Role of the neuroendocrine-immune axis

Gary MEADOWS, USA (Co-chair) - Alcohol consumption: A double edged sword with regard to melanoma metastasis and progression

9C - Molecular/Cell Biology	Room C
Epigenetic basis of alcoholic organ damage

Shivendra SHUKLA, USA (Chair)

Min YOU, USA - SIRT1 signaling in alcoholic fatty liver

Annayya AROOR, USA - Phosphorylation, methylation and acetylation of histone H3 by ethanol: Characteristics and mechanisms

Wataru UKAI, Japan - Alcohol induced neurogenetic dysfunction: Roles of transcription factors and epigenetic regulation

Michele RAMSAY, South Africa - Alcohol induced epigenetic effects on imprinted genes in human sperm DNA: Implications for fetal alcohol spectrum disorders

4A - Determinants of alcohol consumption in humans	Room D
Individual and contextual influences on the development of drinking during adolescence and emerging adulthood

Fulton CREWS, USA (Co-chair and Discussant)

Helene WHITE, USA (Co-chair) - The association between heavy drinking and changes in impulsivity among adolescent males

Kenneth SHER, USA - Dual trajectories of neuroticism and impulsivity in emerging and young adulthood: Relation to course of drinking and psychological distress

Reinout WIERS, The Netherlands - Assessing and changing cognitive motivational processes in adolescent and emerging adult alcohol misuse

Rutger ENGELS, The Netherlands - The booze, the bar and the others: Studies of peer influences on alcohol use during emerging adulthood

12G - Pharmacology CNS	Room E
Neural effects of alcohol interactions with cannabinoids and endocannabinoids

David LOVINGER, USA (Chair)

Giuseppe TALANI, Italy - Ethanol actions on GABAergic transmission in the basolateral amygdala: Interaction with the endocannabinoid system

Paul SCHWEITZER, USA - Physiological interactions of alcohol and cannabinoids on inhibitory transmission in the central amygdala

Jose Antonio LOPEZ-MORENO, Spain - Cannabinoid receptor activation during alcohol abstinence: From neuropharmacology and behavior to neurogenesis in the adult rat brain, and beyond

Basalingappa HUNGUND, USA - Differences in the components of the striatal endocannabinoid signaling system during voluntary alcohol consumption in sP and sNP rats

11B - Pharmacokinetics & Metabolism	Room F
Acetate and brain energy metabolism

Ting-Kai LI, USA (Co-chair)

Sam ZAKHARI, USA (Co-chair) - Alcohol metabolism by hepatic and extrahepatic tissues

Sergey ZIMATKIN, Belarus - Acetate-dependent mechanisms of inborn tolerance to alcohol

Richard VEECH, USA - The utilization of acetate by brain decreases phosphorylation potential and redox states compatible with the opening of the mitochondrial permiability transition pore

Graeme MASON, USA - Acetate transport and utilization in the brain: Characterization and ability to change

Poster Session

16.30-18.00 / Tuesday 14

Merck Serono Satellite Symposium	16.30-18.00 / Tuesday 14

Acamprosate:	Room A - Simultaneous translation
From research on neuroprotection to clinical evidence

Chairmen: Michel LEJOYEUX, France, Michel REYNAUD, France, Barbara MASON, USA, Philippe LEHERT, France

Introduction: Michel REYNAUD

Philippe DE WITTE, Belgium - The neuroprotective effects of acamprosate

Barbara MASON, USA - Evaluation of craving and sleep in a human laboratory study of acamprosate, naltrexone and placebo in alcohol dependent volunteers

Wim VAN DEN BRINK, The Netherlands - Role of motivation and compliance in the pharmacological treatment of alcohol dependence

Michel LEJOYEUX, France - Alcohol use disorders and depression: Results from individual patient data meta analysis of the acamprosate controlled studies

Pascal PERNEY, France - Effect of acamprosate on sleeping disorders during a 24 week follow-up after alcohol withdrawal

Conclusion: Michel LEJOYEUX

Keynote Lectures

8.30-10.00 / Wednesday 15

Pier Vincenzo PIAZZA, Bordeaux, France

Transition to addiction: Drugs or individuals?

Susumu HIGUCHI, Kanagawa, Japan

Alcoholics with inactive aldehyde dehydrogenase-2: What can we learn?

Symposia

10.30-12.00 / Wednesday 15

2B - Brain Imaging	Room A - Simultaneous translation
Alcoholism’s damaging effect on the brain: Insights from international neuroimaging projects INSERM-NIAAA research program

Michel REYNAUD, France (Co-chair)

Jean-Luc MARTINOT, France - Brain imaging techniques and their contribution for studies on alcoholism’s damaging effects

Sandra CHANRAUD, USA - Heterogeneity of brain dysmorphology in human alcoholism: US-France collaborative project

Edith SULLIVAN, USA (Co-chair) - Neural systems, circuitry, and function: Effects of alcoholism

Adolf PFEFFERBAUM, USA - Insights from human and animal neuroimaging studies of alcoholism

10C - Pathology: Human/Animal	Room B
Pathophysiological mechanisms of alcoholic liver disease

Sophie LOTERSZTAJN, France (Co-chair)

Antoine HADENGUE, Switzerland - From bench to bedside: Is the road trickier in alcoholic liver disease?

Bin GAO, USA - Molecular mechanisms of alcoholic liver disease: Roles of cytokines

Ramon BATALLER, Spain - Molecular mechanisms of liver fibrosis

George KUNOS, USA (Co-chair) - Targeting peripheral CB1 cannabinoid receptors for the treatment of alcoholic fatty liver disease

3E - Consequences of alcohol consumption in humans	Room C
Binge alcohol consumption in humans and rodents: Current research findings

Theodora DUKA, United Kingdom (Co-chair) - Cognitive and emotional processes in binge and non binge drinkers

Peter SYAPIN, USA (Co-chair) - Cognitive and functional brain effects of binge drinking in humans and intermittent oral binge alcohol effects in adolescent rats

Iain MCGREGOR, Australia - Studies of adolescent binge drinking and its consequences using the beer model in rats

Moriah STRONG, USA - Binge drinking experience in adolescent mice: Implications for adult alcohol abuse

9B - Molecular/Cell Biology	Room D
Brain stress systems, extended amygdala and the neurobiology of alcoholism INSERM-NIAAA research program

Brigitte KIEFFER, France (Co-chair)

George KOOB, USA (Co-chair) - Extended amygdala neurocircuitry in alcoholism

Robert MESSING, USA - Regulation of neuropeptide signalling by PKC isozymes in the amygdala

Julie LE MERRER, France - Genetic regulations by drugs of abuse: A unique gene collection in the extended amygdala

Candice CONTET, USA - Ethanol dependence through the genetic lens: Focus on genes mediating excessive alcohol intake in the mouse

12J - Pharmacology CNS	Room E
GABA-A receptor subunit selectivity in alcohol action: Focus on δ subunit

Ronald ALKANA, USA (Co-chair)

Martin WALLNER, USA (Co-chair) - High sensitivity to gaboxadol and ethanol of δ subunit-containing GABA(A) receptors

Jing LIANG, USA - Ethanol-induced GABAR plasticity in rat hippocampus: Rapid down-regulation of α4/δ subtypes

Daya PERKINS, USA - Changing the structure of extracellular domain loop 2 in glycine and GABA-A receptors markedly alters ethanol sensitivity and suggests mechanisms of ethanol action

Giovanni BIGGIO, Italy - Regulation of α4/δ GABAA receptors in the hippocampus of socially isolated mice exposed to voluntary ethanol consumption

19A - Treatment/Recovery	Room F
Symposium honoring Helena Stibler: The CDT story

Boris TABAKOFF, USA (Chair)

Stefan BORG, Sweden - The discovery of carbohydrate deficient transferring-the first years

Anders HELANDER, Sweden - The standardization of CDT as an alcohol use marker (performance and pitfalls)

John WHITFIELD, Australia - The Australian experience with CDT

Raymond ANTON, USA - Past, current, and future clinical and research use of CDT

Poster Session

12.00-13.00 / Wednesday 15

Symposia

13.00-14.30 / Wednesday 15

4H - Determinants of alcohol consumption in humans	Room A - Simultaneous translation
Alcohol and cannabis use disorder: Recent epidemiological, clinical and genetic data to advance our understanding of addictions

Amine BENYAMINA, France (Co-chair)

Hilde PAPE, Norway - Alcohol and cannabis: Two of a kind? Alcohol and cannabis use among adolescents

Lisa BLECHA, France - Alcohol and cannabis dependence: Chronology, neurobiology and genes

Mary Jeanne KREEK, USA (Co-chair) - Human genetic variants of the CB1, FAAH and mu opioid receptor gene: Implications for alcoholism and opioid-cannabinoid interactions

9D - Molecular/Cell Biology	Room B
Novel molecules and mechanisms in alcoholic and non-alcoholic cirrhosis: Commonalities and differences

Devanshi SETH, Australia (Chair) - Role of secreted phosphoprotein 1 (SPP 1) in alcoholic liver cirrhosis

Soichi KOJIMA, Japan - Induction of transglutaminase 2 during the pathogenesis of both alcoholic steatohepatitis and non-alcoholic steatohepatitis

Anna Mae DIEHL, USA - Hedgehog pathway activation and pathogenesis of cirrhosis in alcoholic and nonalcoholic fatty liver disease

Anna GUKOVSKAYA, USA - Lysosomal dysfunction and impaired autophagy in alcoholic pancreatitis

Katja BREITKOPF, Germany - Impact of the Smad-1/5/8 TGF-β pathway on liver damage and hepatic regeneration

3F - Consequences of alcohol consumption in humans	Room C
Hangover and other residual alcohol effects: Predictors and consequences

Jonathan HOWLAND, USA (Co-chair) - Hangover sensitivity predicts residual alcohol effects on attention reaction time

Damaris ROHSENOW, USA (Co-chair) - Hangover sensitivity in college does not predict transition to post-college drinking

Chris STREETER, USA - Compensatory recruitment of prefrontal cortex during correct responses in a continuous performance task during a hangover condition compared to a placebo condition

John MCGEARY, USA - Genetic variation associates with hangover the morning after drinking to intoxication: Analyses of alcohol dehydrogenase polymorphisms

Joris VERSTER, The Netherlands (Discussant)

2A - Brain Imaging	Room D
Advances in alcohol brain imaging: The use of BOLD fMRI and PET to better understand reward learning, treatment response, medications development and genetic diversity

Andreas HEINZ, Germany - Imaging of neurobiological correlates of learning dysfunction in alcoholism

Sabine VOLLSTADT-KLEIN, Germany - Cue-reactivity in alcohol-dependence and social drinking

Hugh MYRICK, USA - Imaging and alcoholism: From cue-induced activation to therapeutic interventions

Kent HUTCHISON, USA - Alcohol dependence: Neuroimaging phenotypes and genome wide arrays

Raymond ANTON, USA (Discussant)

12D - Pharmacology CNS	Room E
The "aperitif" hypothesis of alcohol consumption

Paula HOFFMAN, USA (Co-chair) - Genetical genomic determinants of alcohol consumption by rats

David MOORMAN, USA - A prominent role of the orexin/hypocretin system in alcohol preference and consumption

Sarah LEIBOWITZ, USA - Alcohol intake and orexigenic peptides

Suzanne DICKSON, Sweden (Co-chair) - The central ghrelin signalling system in alcohol and food reward

Thomas HILLEMACHER, Germany - Leptin, craving and CAG trinucleotide repeats of the androgen receptor

19B - Treatment/Recovery	Room F
Translational approach to novel medications development for the treatment of alcohol dependence

John LITTLETON, USA - Novel NMDA receptor modulators as neuroprotective anti-relapse agents

Markus HEILIG, USA - Imaging based surrogate markers as translational tools in medications development for alcoholism

Dennis RASMUSSEN, USA - Translational approach to development of noradrenergic agents for treatment of alcohol dependence

Barbara MASON, USA - Human laboratory and clinical trial evidence for gabapentin treatment of alcohol dependence

George KOOB, USA (Chair) - Theoretical framework for a rosetta stone approach to medications development for alcoholism

Symposia

14.30-16.00 / Wednesday 15

19K - Treatment/Recovery	Room A - Simultaneous translation
Liver diseases, alcohol abuse and addictions combined management: A new French model of collaboration to eradicate hepatitis C virus Supported by an unrestricted educational grant of Roche SAS

Valérie CANVA, France - Long-term impact of alcohol consumption on hepatitis C-related morbidity and mortality: A modelling approach in France underlying absolute necessity for hepatologist and addictologist to work in close collaboration

Pascal MELIN, France - Management of psychiatric disorders and addictive behaviors in patients with viral hepatitis C in France: Current clinical practices, impact on disease management and perspectives

Eve GELSI, France - Treatment of chronic hepatitis C virus in heavy drinkers: Is it possible?

Victor DE LEDINGHEN, France (Chair) - Impact of non-invasive evaluation of liver fibrosis on HCV screening and management in street-based outreach for drug users

9E - Molecular/Cell Biology	Room B
Novel modulators of alcoholic liver injury: From stem cells to epigenetics

Hide TSUKAMOTO, USA (Co-chair)

Raj LAKSHMAN, USA (Co-chair) - Roles of PGC-1 transcriptional co-activators in alcoholic liver injury

Sophie LOTERSZTAJN, France - Role of Kupffer cells in the pathogenesis of alcoholic liver disease

Keigo MACHIDA, USA - TLR4-dependent Nanog+ cancer stem cells exhibit defective TGF-β signaling in alcoholic liver injury

José M. MATO, Spain - Understanding Best: Lipotropic activity of methionine

3H - Consequences of alcohol consumption in humans	Room C
Alcohol consumption, HIV infection, and cardiovascular disease

Matthew FREIBERG, USA (Co-chair) - Past and hazardous alcohol consumption, alcohol abuse and dependence and the risk of incident cardiovascular diseases

Jeffrey SAMET, USA (Co-chair) - HIV, Hepatitis C co-infection and levels of inflammatory biomarkers typically associated with CVD risk

M. Patrizia CARRIERI, France - Alcohol consumption and cardiovascular disease (CVD) in HIV-infected patients receiving antiretroviral treatment (ART): Results from the ANRS CO8 APROCO-COPILOTE cohort

Kendall BRYANT, USA (Discussant)

10B - Pathology: Human/Animal	Room D
Alcohol and neuroinflammation

Antonio NORONHA, USA (Co-chair)

Clive HARPER, Australia - Structural changes in the human brain related to alcohol dependence – Are there inflammatory mechanisms?

Fulton T. CREWS, USA - Alcohol induction of proinflammatory genes causes neurodegeneration: Key roles of NFkB transcription and oxidative stress

Yuri PERSIDSKY, USA - Inflammatory responses caused by alcohol brain endothelial cells and astrocytes: Role in neurodegeneration

Consuelo GUERRI, Spain (Co-chair) - Role of TLR4 receptors on ethanol-induced neuroinflammation and neurodegeneration

12C - Pharmacology CNS	Room E
Medications development: Contributions of rodent models of alcohol drinking

Ting-Kai LI, USA (Co-chair and Discussant)

Janice FROEHLICH, USA (Co-chair) - Medications development: Relevance and advantage of rodent models of alcohol drinking

Anh Dzung LE, Canada - Co-morbidity of alcohol and nicotine: Alterations in responses to naltrexone and varenicline

Giancarlo COLOMBO, Italy - Reduction of alcohol self-administration by the positive allosteric modulators of the GABA(B) receptor in alcohol-preferring rats

Lina YAO, USA - A novel ALDH2 Inhibitor based on ancient Chinese medicine is highly effective in preventing alcoholism-related increases in accumbens dopamine, suppressing drinking and preventing craving and relapse even when alcohol is not offered (no acetaldehyde)

19J - Treatment/Recovery	Room F
The role of cue-reactivity and extinction in the treatment of alcohol addiction

Reinout WIERS, The Netherlands (Co-chair) - Re-training attentional bias and approach bias for alcohol in alcoholic patients

Anders HAMMARBERG, Sweden - The effect of acamprosate on alcohol-priming induced craving

Falk KIEFER, Germany (Co-chair) - Effect of cue-exposure based training on fMRI cue-reactivity in alcohol-dependent subjects

Wendy OOTEMAN, USA - Predicting the effect of naltrexone and acamprosate on cue-induced craving in alcohol-dependent patients using genetic indicators

Poster Session

16.30-18.00 / Wednesday 15

Keynote Lectures

8.30-10.00 / Thursday 16

Michel LEJOYEUX, Paris, France

Alcohol addiction and behavioral dependence

Karl MANN, Heidelberg, Germany

What about biology? Contributions towards a personalized treatment of alcoholism

Symposia

10.30-12.00 / Thursday 16

19G - Treatment/Recovery	Room A - Simultaneous translation
Reduced drinking as an alternative treatment goal Supported by an unrestricted educational grant of Lundbeck

Karl MANN, Germany (Co-chair)

Mark B. SOBELL, USA - A historical overview of controlled drinking: Fiddling while Rome burns

Henri-Jean AUBIN, France (Co-chair) - Black or white alcohol outcomes in Europe

Mark WILLENBRING, USA - What is the disorder? What is the outcome? Thoughts on goals and outcomes for treating heavy drinking

Ting-Kai LI, USA (Discussant)

15B - Psychiatric Comorbidity	Room B
Alcohol and neuropsychiatric disorders

Yousef TIZABI, USA (Co-chair) - Alcohol and depression: Role of biogenic amines and neurotrophic factors

Subhash PANDEY, USA (Co-chair) - The co-morbidity of anxiety and alcoholism: A perspective from epigenetic studies

Toshikazu SAITO, Japan - Stem cell regulation as a new treatment strategy for alcoholism and other psychiatric disorders

Dai-Jin KIM, Republic of Korea - Alcohol and cognition

10E - Pathology: Human/Animal	Room C
Impact of altered methylation in cytokine signaling and proteasome function in alcohol and viral-mediated diseases

Kusum KHARBANDA, USA (Co-chair)

Natalia OSNA, USA (Co-chair) - Impaired methylation reactions suppress MHC Class I-restricted antigen presentation by modulation of proteasome function and interferon γ signaling

Shirish BARVE, USA - Role of S-adenosylmethionine (SAM) mediated epigenetic modifications in the dysregulated TNF expression induced by alcohol

Patricia MOLINA, USA - Chronic alcohol and SIV infection; enhanced proteasome-mediated loss of muscle mass

Fawzia BARDAG-GORCE, USA - Ethanol-induced proteasome inhibition is associated with changes in methylation: Effects of S-adenosylmethionine

9K - Molecular/Cell Biology	Room D
Alcohol and organelle dysfunction: Using organelle-focused studies to determine alcohol’s mechanism of action

Shannon BAILEY, USA - Use of proteomics to elucidate alcohol-mediated alterations to the mitochondrial proteome in alcoholic liver disease

María del Pilar MARIN, Spain - Chronic alcohol alters the structure and function of Golgi complex in nervous cells

Alan CAHILL, USA - The detrimental impact of chronic ethanol feeding on the structure and function of the hepatic mitoribosome

Joseph SISSON, USA (Chair) - Direct effects of alcohol on the function of isolated airway cilia

Elizabeth J. KOVACS, USA (Discussant)

12F - Pharmacology CNS	Room E
Desensitization of ligand-gated ion channels: A contributor to molecular tolerance to alcohol exposure?

Alex DOPICO, USA (Co-chair)

David LOVINGER, USA (Co-chair) - Desensitization involvement in opposing ethanol effects on AMPA/glutamate and 5-HT3 receptors

Toshio NARAHASHI, USA - Significance of ethanol modulation of nicotinic acetylcholine receptors

Neil HARRISON, USA - Alcohol and GABA-A receptors in the CNS

László KOLES, Hungary - Desensitization of excitatory amino acid and P2X receptor currents by ethanol and trichloroethanol

19D - Treatment/Recovery	Room F
Implementation and outcomes of brief interventions in medical centers conducted in England, Poland, and the United States: Drinking, quality of life, and cost effectiveness

Jacek MOSKALEWICZ, USA (Co-chair)

Colin DRUMMOND, United Kingdom - Implementing screening and brief intervention in emergency departments in England

Eileen F.S. KANER, United Kingdom - Screening and brief alcohol intervention in routine primary care in the UK: SIPS trial outcomes at six months

Peter MONTI, USA (Co-chair) - Six and twelve month outcomes of brief alcohol interventions in trauma and emergency departments

Nancy BARNETT, USA (Discussant)

Poster Session

12.00-13.00 / Thursday 16

Symposia

13.00-14.30 / Thursday 16

19E - Treatment/Recovery	Room A - Simultaneous translation
Cocaine and alcohol addiction: Clinical aspects and therapeutic approaches of dual alcohol and cocaine abuse and dependence Supported by an unrestricted educational grant of Schering-Plough France

Olivier COTTENCIN, France - Clinical aspects of cocaine and alcohol addiction

Daniele ZULLINO, Switzerland - Does topiramate target the core mechanism of addiction? The cocaine and alcohol experiences

Laurent KARILA, France (Chair) - Pharmacotherapies of dual alcohol and cocaine abuse and dependence

Kathleen CARROLL, USA - Psychotherapies for comorbid alcohol and cocaine use

15A - Psychiatric Comorbidity	Room B
Comorbidity of mood disorders and alcohol dependence: Course and treatment

Margaret GRIFFIN, USA (Co-chair)

Anabel MARTINEZ-ARAN, Spain - Cognitive impairment in bipolar patients with and without prior history of alcohol use

Roger WEISS, USA (Co-chair) - Integrated group therapy for patients with bipolar disorder and substance dependence

Franz MOGGI, Switzerland - Depressive symptoms as a predictor of alcohol relapse after residential alcohol use disorder treatment programs

Conor K. FARREN, Ireland - A 2-year follow up of alcoholics with depression and bipolar disorder following an integrated inpatient treatment program

9H - Molecular/Cell Biology	Room C
Epigenetics, development and alcohol

Ulrike HEBERLEIN, USA - Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors

Joseph NAPOLI, USA - Ethanol elevates physiological all-trans-retinoic acid levels in select loci through altering retinoid metabolism in multiple loci: A potential mechanism of ethanol toxicity

Abraham FAINSOD, Israel - Ethanol induces embryonic malformations by competing for retinaldehyde dehydrogenase activity during vertebrate gastrulation

Kornel SCHUEBEL, USA (Discussant)

9G - Molecular/Cell Biology	Room D
Molecular mechanisms of alcoholic liver disease

Hélène ROUACH, France (Co-chair)

Hide TSUKAMOTO, USA - Synergistic steatohepatitis caused by obesity and alcohol

Laura NAGY, USA - Ethanol and signal transduction: Regulation of cytokine production by Kupffer cells

José C. FERNANDEZ-CHECA, Spain - StAR expression and peroxidized cardiolipin in alcohol-induced liver injury

Michèle GARLATTI, France (Co-chair) - ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes

12I - Pharmacology CNS	Room E
Role of glutamate in alcohol dependence and drinking

David N. STEPHENS, United Kingdom (Co-chair)

Howard C. BECKER, USA (Co-chair) - Effects of chronic intermittent ethanol exposure and drinking on extracellular glutamate levels in the accumbens of C57BL/6J mice

Friedbert WEISS, USA - Effects of mGLu2/3 and mGlu5 manipulation on ethanol seeking and reinforcement: Modification by history of ethanol dependence

Wolfgang SOMMER, Germany (Co-chair) - Magnetic resonance spectroscopy in medial prefrontal cortex and hippocampus of ethanol dependent rats during intoxication, withdrawal and protracted abstinencese disorders

Dieter J. MEYERHOFF, USA - Metabolite levels by magnetic resonance spectroscopy during abstinence from alcohol: Focus on glutamate

19L - Treatment/Recovery	Room F
Guidelines for alcohol pharmacotherapy trials: Hot topics in study design and methods INSERM-NIAAA research program

Margaret M. MURRAY, USA (Chair)

Karl BROICH, Germany - Requirements on clinical trials for the treatment of alcohol dependence – A European regulatory perspective

Daniel FALK, USA - Percentage of subjects with no heavy drinking days: Evaluation as an efficacy endpoint for alcohol clinical trials

Bankole JOHNSON, USA - Innovative analytic methods of person-centered data for alcohol treatment research

Raye LITTEN, USA - New strategies and approaches to improve alcohol clinical trials and inform regulatory guidance

Symposia

14.30-16.00 / Thursday 16

15C - Psychiatric Comorbidity	Room A - Simultaneous translation
Bipolar disorders and alcoholism: Clinical, genetic and therapeutic approaches Supported by an unrestricted educational grant of Sanofi-Aventis France

Pierre Michel LLORCA, France (Co-chair)

Jean Pierre LEPINE, France (Co-chair and Discussant)

Icro MAREMMANI, Italy - Bipolar disorders and affective temperaments in alcoholic patients

Philip GORWOOD, France - Genetics of addictive behaviours in the community

Ihsan SALLOUM, USA - Therapeutic approaches for bipolar disorder with comorbid alcoholism

3I - Consequences of alcohol consumption in humans	Room B
Neurobehavioral systems underlying alcohol-related emotional and cognitive dysregulation

Sara Jo NIXON, USA (Chair)

Xavier NOEL, Belgium - Difficulties encountered to regulate alcohol intake reflect the interaction between cognitive biases and prepotent response inhibition deficits

Hélène BEAUNIEUX, France - Alcoholism and structural abnormalities in the frontal cortex: Contribution to metamemory and decision making impairments

Marlene OSCAR-BERMAN, USA - Alcoholism, emotion, and brain reward circuitry

Marsha BATES, USA - Family history, vulnerability mechanisms, and emotional dysregulation

10G - Pathology: Human/Animal	Room C
Molecular mechanisms of alcoholic liver disease: Roles of endocytosis, PARP, TGF-β

Bin GAO, USA (Co-chair)

Carol CASEY, USA - The role of impaired receptor-mediated endocytosis in the development of alcoholic liver injury

Pal PACHER, USA (Co-chair) - Role of poly(ADP-ribose) polymerase (PARP) in hepatic inflammation and fibrosis

Steven DOOLEY, Germany - TGF-β enhances adverse alcohol effects and hepatocellular damage

Won-Il JEONG, Republic of Korea - Role of natural killer cells/TGF-β in alcoholic liver fibrosis

3A - Consequences of alcohol consumption in humans	Room D
Alcohol and damages on skeletal muscles and bones

Françoise J. BEAUGE, France (Chair)

Thomas VARY, USA - Altered protein metabolism contributes to striated muscle damage following alcohol abuse

Emilio GONZALEZ-REIMERS, Spain - Clinical and prognostic value of lean and fat mass in alcoholics

Delphine MAUREL, France - Alcohol consumption: A risky behaviour for bone health

Peter MALIK, Austria - The course of several markers of bone metabolism over 8 weeks of abstinence in young male alcoholics

18A - Training/Education Methods	Room E
The science of dissemination: Which physician training strategies make a difference?

Margaret M. MURRAY, USA - Using dissemination science to increase physician identification and treatment of alcohol problems

Larissa TSVETKOVA, Russia - Brief intervention and FASD training for physicians: Results of a randomized trial

Kevin RUDEEN, USA (Chair) - Training center prevention effectiveness for fetal alcohol spectrum disorder interventions for health care providers in a midwest region of the United States

Antoni GUAL, Spain - The role of motivation in the success of dissemination strategies

John SAUNDERS, Australia (Discussant)

19I - Treatment/Recovery	Room F
Screening and brief intervention: Current challenges regarding efficacy and implementation

Richard SAITZ, USA (Chair and Discussant)

John CUNNINGHAM, Canada - What would it take to show a population level impact of electronic structured brief interventions for drinking problems?

Jean-Bernard DAEPPEN, Switzerland - Efficacy of brief motivational intervention at army conscription to address alcohol use and related problems: A randomized controlled trial

Gail D'ONOFRIO, USA - Brief intervention for hazardous and harmful drinkers in the ED

Katharine BRADLEY, USA - Effects of the proportion screening positive on a performance measure for brief alcohol intervention

J. Paul SEALE, USA - Implementing alcohol screening and brief intervention in US Primary Care Residency Programs - Lessons learned

Poster Session

16.30-18.00 / Thursday 16